Abstract Background Protein sequence evolution is constrained by the biophysics of folding and function, causing interdependence between interacting sites in the sequence.However, current site-independent models of sequence evolutions do not take this into account.Recent attempts to integrate the influence of structure and biophysics into phylogene
The distribution of functional traits within and across spatiotemporal scales has been used to quantify and infer the relative resilience across ecosystems.We use explicit spatial modeling to evaluate within- and cross-scale redundancy in headwater streams, an ecosystem type with a hierarchical and dendritic network structure.We assessed the cross-
Abstract Accurate fluid flow simulation in geologically complex reservoirs is of particular importance in construction of reservoir simulators.General approaches in naturally fractured reservoir simulation involve use of unstructured grids or a structured grid coupled with locally unstructured grids and discrete fracture models.These methods suffer
The high level of serum cholesterol caused by the excessive absorption of cholesterol can lead to hypercholesteremia, thus promoting the occurrence and development of cancer.Ezetimibe is a drug that reduces cholesterol absorption and has been widely used for the treatment of patients with high circulating cholesterol levels for many years.Mechanist
Summary: When conversing, humans instantaneously predict meaning from fragmentary and ambiguous mspeech, long before utterance completion.They do this by integrating priors (initial assumptions about the world) with contextual evidence to rapidly Womens wetsuit decide on the most likely meaning.One powerful prior is attentional preference for agent